3D human organ-on-chip disease model
Welcome to the era of micro-organ engineering, where the future of drug discovery is being transformed.
We have developed a high-throughput organ chip culture system that enables us to replicate the multi-cellular environment of human organs in a controllable laboratory setting. By leveraging cutting-edge microfluidic chips with different channel designs, functional capabilities, connectivity, and throughput, we are pushing the boundaries of understanding complex human pathobiology and accelerating drug discovery.
3D Human-on-Chip Disease Modeling
High throughput automated perfusion and culture assistance
Traditional drug discovery efforts have often relied on simplified animal models that have poor translational validity, limiting our understanding of the complex interactions within the human body. By developing dynamic 3D tissue and organ models, we are determined to offer a holistic view of human biology.
Xellar’s Preclinical Development Platform enables the creation of tissue/organ chip disease models, built upon our proprietary high throughput barrier-free 3D organ chip technology. Our closed-loop disease model platform allows for the study of disease progression, drug responses, and the evaluation of therapeutic interventions in a more accurate and predictive context.
Full automated high-throughput high-content imaging and analysis pipeline and feature extraction
Understanding the intricacies of human biology requires the ability to capture and analyze the smallest details. At Xellar biosystems, our high-throughput, high-content data platform incorporates cutting-edge imaging technologies to enable comprehensive analysis of cellular and tissue-level responses within our organ-on-chip models.
We use high-content, lost cost, and rapid staining approaches to capture sub-cellular morphology. We then leverage fully automated high-resolution confocal microscopy to observe live cells for viability and treatment responses throughout the culture period, in addition to capturing detailed endpoint images of cells cultured in 3D environment. Together, our fully automated high-throughput imaging systems capture spatial and temporal information with exceptional clarity.
Multiplexed and Multimodal data analysis and integration
At Xellar Biosystems, we recognize that the vast amount of biological and imaging data generated from our experiments requires advanced computational tools for efficient analysis and interpretation. Our Computation platform is specifically designed to handle and extract meaningful insights from complex datasets, leveraging the power of Artificial Intelligence (AI) and Machine Learning (ML) algorithms.
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